Fat Deposition in Osseous Tissue of Femur

      Under light microscope we can see that adipose tissue in femoral heads of the model rats ( model of femoral head necrosis) increases, trabecula in those become lesser and thinner, adipose ratio of osteocytes and chondrocytes of those obviously increases (see figure 13,14). However, no or little fat drops can be seen in normal rats (see figure 11,12). The “Chengzai pill” therapeutic rats are the same as the normal ones (see figure 15,16). 

Figure 11(*200), Fat drops can not be seen in osteocytes of normal femoral head. Rich sinusoids can be seen in the medullary cavity. Figure12(*400) A few fat drops can be seen in chondrocytes of normal femoral head.
Figure 13(*200), A great deal of fat drops can be seen in osteocytes of femoral head of model rats (model of femoral head necrosis). Figure 14(*400) A great deal of fat drops can be seen in chondrocytes of femoral head of model rats (model of femoral head necrosis).
Figure15(*400), No fat drops can be seen in osteocytes of the femoral head of “Chengzai pill” group. Rich sinusoid can be seen in the medullary cavity. Figure 16(*400), A few fat drops can be seen in chondrocytes of the femoral head of “Chengzai pill” group.

Table4: Effects brought by “Chengzai pill” on adipose staining in osteocytes of femur

Group n Adipose staining ratio of chondrocytes (%) Adipose staining ratio of osteocytes(%)
Normal contrast group 5 2.32±1.83 0.81±0.82
Model contrast group 5 49.74±13.85
▲▲
48.54±18.07
▲▲
“Chengzai pill” therapeutic group 5 20.69±9.26
△△
5.03±5.01
△△
▲▲   compared with normal contrast group P<0.01
△△   compared with model group P<0.01

              normal model  “Chengzai pill”

Chart4 Effects brought by “Chengzai pill” on adipose staining in osteocytes of femur

 

From chart16 and table4 we can see that adipose staining ratio in chondrocytes of the model rats (model of femoral head necrosis) is obviously higher than that of normal group (p<0.01). After the model rats are poured “Chengzai pill”, the ratio is obviously decreases.

Copy right by: Beijing Emperor Special Hospital of Femur Head Necrosis